Publications
Peer-reviewed research from FengLab.
FengLab research
Publications
Research spanning human systems immunology, vaccine responses, antibody discovery, and the interaction between the microbiome and immune function.
Featured publication
2025
Cell Host & Microbe · 33(5), 705–718.e5
Antibiotic-induced gut microbiome perturbation alters the immune responses to the rabies vaccine
A study of how antibiotic-driven perturbation of the gut microbiome relates to immune responses following rabies vaccination.
View publicationSelected by the journals
Cover Features
Three studies were selected for journal cover features, highlighting work in vaccine design, memory B-cell biology, and microbiome–immune regulation.
Publication record
Research articles
Listed in reverse chronological order. Titles link to the original journal or publisher record.
2025
Cell Host & Microbe · 33(5), 705–718.e5
Antibiotic-induced gut microbiome perturbation alters the immune responses to the rabies vaccine
Cell Reports Medicine · 6(4)
Altered baseline immunological state and impaired immune response to SARS-CoV-2 mRNA vaccination in lung transplant recipients
2024
Science Immunology · 9(94), eadi8039
AS03 adjuvant enhances the magnitude, persistence, and clonal breadth of memory B cell responses to a plant-based COVID-19 vaccine in humans
Science Translational Medicine · 16(758), eadn6605
A comparative immunological assessment of multiple clinical-stage adjuvants for the R21 malaria vaccine in nonhuman primates
2023
Journal of Clinical Investigation · 133(10)
Durability of immune responses to mRNA booster vaccination against COVID-19
Nature Immunology · 24(2), 337–348
SREBP signaling is essential for effective B cell responses
Cell · 186(21), 4632–4651.e23
Multi-omics analysis of mucosal and systemic immunity to SARS-CoV-2 after birth
Science Translational Medicine · 15(695), eadg7404
Broadly neutralizing antibodies against sarbecoviruses generated by immunization of macaques with an AS03-adjuvanted COVID-19 vaccine
2022
Nature Immunology · 23(4), 543–555
Mechanisms of innate and adaptive immunity to the Pfizer-BioNTech BNT162b2 vaccine
Science Translational Medicine · 14(658), eabq4130
Durable protection against the SARS-CoV-2 Omicron variant is induced by an adjuvanted subunit vaccine
npj Vaccines · 7, 55
Adjuvanting a subunit SARS-CoV-2 vaccine with clinically relevant adjuvants induces durable protection in mice
2021
Nature · 596(7872), 410–416
Systems vaccinology of the BNT162b2 mRNA vaccine in humans
2020
Science · 369(6508), 1210–1220
Systems biological assessment of immunity to mild versus severe COVID-19 infection in humans
2019
Frontiers in Immunology · 10, 2426
Phenotypic characterization of Chinese rhesus macaque plasmablasts for cloning antigen-specific monoclonal antibodies
2018
npj Vaccines · 3, 29
Incorporation of NS1 and prM/M are important to confer effective protection of adenovirus-vectored Zika virus vaccine carrying E protein
Journal of Biomedical Nanotechnology · 14(10), 1806–1815
Oral delivery of bavachinin-loaded PEG-PLGA nanoparticles for asthma treatment in a murine model
Virology · 518, 272–283
Hexon and fiber of adenovirus type 14 and 55 are major targets of neutralizing antibody but only fiber-specific antibody contributes to cross-neutralizing activity
Emerging Microbes & Infections · 7(1), 1–12
An adenovirus serotype 2-vectored ebolavirus vaccine generates robust antibody and cell-mediated immune responses in mice and rhesus macaques
2016
Scientific Reports · 6, 25856
Potent neutralizing monoclonal antibodies against Ebola virus infection
2015
International Journal of Nanomedicine · 1743–1757
Specifically targeted delivery of protein to phagocytic macrophages
2014
International Journal of Pharmaceutics · 465(1–2), 378–387
A novel multifunctional poly (amidoamine) dendrimeric delivery system with superior encapsulation capacity for targeted delivery of the chemotherapy drug 10-hydroxycamptothecin
Organic & Biomolecular Chemistry · 12(29), 5365–5374
An intracellularly activatable, fluorogenic probe for cancer imaging
Corrections
2023 · Nature 618, E18 Author Correction: Systems vaccinology of the BNT162b2 mRNA vaccine in humans